The following is a list of publications and presentations that highlight both clinical results and the research and development activities of Focus Surgery in the areas of High Intensity Focused Ultrasound - HIFU.
The Clinical publications include papers from Focus Surgery as well as general clinical results from other practitioners.
The Research & Development publications and presentations cover a number of topics including HIFU phased arrays, novel non-invasive treatment monitoring, clinical data, laparoscopic and catheter-based delivery of HIFU, and other methods and devices related to HIFU, cancer treatment, transducers, electronics, devices, etc.
The papers listed below are
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Prostate Cancer
H. Ahmed, D. Pendse, R. Illing, C. Allen, J. van der Meulen, M. Emberton, "Will focal therapy become a standard of care for men with localized prostate cancer?" Nature Clinical Practice Oncology, accepted 13 June 2007, Vol. 4, No. 11, pp. 632-642. [Paper]
T. Uchida, M. Nitta, S. Hongo, S. Shoji, Y. Nagata, Y. Usui, T. Terachi, "High-intensity focused ultrasound for the treatment in 517 patients with localized prostate cancer," presented at the 29th SIU-Congress in Paris, France, September 2007. [Abstract]
E. Zacharakis, H. Ahmed, A. Ishaq, R. Illing, R. Scott, G. Shaw, J. Calleary, C. Allen, M. Emberton, "Visually Directed Primary HIFU for Treating Localized Prostate Cancer," presented at the 29th SIU-Congress in Paris, France, September 2007. [Abstract]
E. Zacharakis, H. Ahmed, A. Ishaq, R. Illing, R. Scott, G. Shaw, J. Calleary, C. Allen, M. Emberton, "Salvage HIFU effectively reduces PSA in patients with biochemical recurrence after attempted curative treatment for prostate cancer," presented at the 29th SIU-Congress in Paris, France, September 2007. [Abstract]
R. Illing, M. Emberton, "Sonablate®-500: transrectal high-intensity focused ultrasound for the treatment of prostate cancer," Future Drugs, Ltd., 2006. [Paper]
T. Uchida, H. Ohkusa, Y. Nagata, T. Hyodo, T. Satoh, A. Irie, "Treatment of localized prostate cancer using high-intensity focused ultrasound," British Journal of Urology, 2006, pp. 56-61. [Paper]
R. Illing, T. Leslie, J. Kennedy, J. Calleary, C. Ogden, M. Emberton, "Visually directed high-intensity focused ultrasound for organ-confined prostate cancer: a proposed standard for the conduct of therapy," British Journal of Urology, 2006, pp. 1187-1192. [Paper]
N. Sanghvi, et.al, "High Intensity Focused Ultrasound for the Treatment of Recurrent Prostate Cancer," presented at the International Society for Therapeutic Ultrasound (ISTU) Symposium in Oxford, UK, August 30 - September 2, 2006. [Abstract]
T. Gardner, M. O. Koch, "Prostate Cancer Therapy with High-Intensity Focused Ultrasound," Clinical Gentourinary Cancer, Vol. 4, No. 3, pp. 187-192, 2005. [Paper]
R. J. Fedewa, R. Seip, R. F. Carlson, W. Chen, N. T. Sanghvi, M. A. Penna, K. A. Dines, & R. E. Pfile, "Automated Treatment Planning for Prostate Cancer HIFU Therapy," Proceedings of the 2005 IEEE International Ultrasonics Symposium, Rotterdam, The Netherlands, 19-21 Sept, 2005. [Paper]
T. Uchida, S. Baba, N. Masumori, T. Tsukamoto, H. Nakatsu, H. Fujimoto, T. Kakazoe, et al., "Transrectal High-Intensity Focused Ultrasound In the Treatment of Localized Prostate Cancer: A Multicenter Study," Acta Urology Japan, #51, pp.651 - 658, 2005. [Paper]
T. Uchida, S. Shoji, Y. Nagata, "HIFU for Localized Prostate Cancer: 6 Year Experience," presented at the International Society for Therapeutic Ultrasound (ISTU5) meeting in Boston, October 2005. [Abstract]
T. Uchida, H. Yamashita, H. Ohkusa and Y. Nagata, "Clinical Outcome of HIFU for the Treatment of Localized Prostate Cancer: 5-Year Experience," to appear in the Proc. of the International Symposium on Therapeutic Ultrasound, 2004. [Abstract]
T. Gardner, M.O. Koch, R. Seip and N.T. Sanghvi, "High Intensity Focused Ultrasound (HIFU) U.S. Experience for Localized Prostate Cancer," to appear in the Proc. of the International Symposium on Therapeutic Ultrasound, 2004. [Abstract]
John C. Rewcastle, Ph.D., "High Intensity Focused Ultrasound for Prostate Cancer: Clinical Results and Technical Evolution," Whitepaper (2004). [Paper]
T. Uchida, H. Tsumura, H. Yamashita, M. Katsuta, D. Ishii, T. Satoh, A. Ohkawa, T. Hyodo, N.T. Sanghvi, “Transrectal High Intensity Focused Ultrasound for Treatment of Patients with Stage T1b-2N0M0 Localized Prostate Cancer: A Preliminary Report,” Japanese Journal of Endourology and ESWL, 2003, pp. 108-114. [Paper]
T. Uchida, N.T. Sanghvi, T.A. Gardner, M.O. Koch, D. Ishii, S. Minei, T. Satoh, T. Hyodo, A. Irie and S. Baba, “Transrectal High Intensity Focused Ultrasound for Treatment of Patients with Stage T1b-2N0M0 Localized Prostate Cancer: A Preliminary Report,” Urology, 2002, pp. 394-399. [Paper]
T. Uchida, N.T. Sanghvi, T. Satoh, A. Irie, T. Omata, S. Baba, M.O. Koch, and T.A. Gardner, "Transrectal High Intensity Focused Ultrasound for the Treatment of Localized Prostate Cancer," Proc. of the International Symposium on Therapeutic Ultrasound, 2002, pp. 8-16. [Paper]
N.T. Sanghvi, T. Uchida, M.O. Koch, and T.A. Gardner, "Total Prostate Ablation for the Treatment of Localized Prostate Cancer Using Image Guided HIFU," presented at the 2002 IEEE Ultrasonics Symposium. [Poster]
T. Uchida, M.D., Kitasato University, Department of Urology, "Localized Prostate Cancer Treatment with HIFU," Translated and updated from The Journal of Highly Advanced Medical Technology, Volume 15 (March 2000).
S. Madersbacher, M. Pedevilla, L. Vingers, M. Susani and M. Marberger, Department of Urology (S.M., M.P., L.V., M.M.) and Pathology (M.S.), University of Vienna, "Effect of High-Intensity Focused Ultrasound on Human Prostate Cancer in Vivo," Cancer Research 55, 3346-3351, (August 1995) [Paper]
BPH - Benign Prostatic Hyperplasia
N. T. Sanghvi, R. S. Foster, R. Bihrle, R. Casey, T. Uchida, M. H. Phillips, J. Syrus, and A. V. Zaitsev, K. W. Marich, F. J. Fry, "Noninvasive Surgery of Prostate Tissue by High-Intensity Focused Ultrasound: An Updated Report," European Journal of Ultrasound, Vol. 9; 19-29, 1999. [Paper]
T. Uchida, M. Muramoto, H. Kyunou, M. Iwamura, S. Egawa and K. Koshiba, "Clinical Outcome of High-Intensity Focused Ultrasound for Treating Benign Prostatic Hyperplasia: Preliminary Report," Urology, 1998:52:66-71. Elsevier Science. [Paper]
K. Nakamura, I. Taketugu, et al"Minimally Invasive Surgery of Benign Prostatic Hyperplasia by High-Intensity Focused Ultrasound: Clinical Efficacy After One-Year Follow-Up," Japanese Journal of Endourology and ESWL, Vol. 11; 55-59, 1998.
T. Uchida and K. Koshiba, "High-Intensity Focused Ultrasound (HIFU) for Treating Benign Prostatic Hyperplasia," Japanese Journal of Endourology and ESWL, Vol. 10; no. 1; 20-22, 1997.
L. D. Sullivan, M. G. McLoughlin, L. G. Goldenburg, M. E. Gleave, and K. W. Marich, "Early Experience with High-Intensity Focused Ultrasound for the Treatment of Benign Prostatic Hypertrophy," British Journal of Urology, 79; 172-176, 1997. [Paper]
N. T. Sanghvi, F. J. Fry, R. Bihrle, R. S., Foster, M. H. Phillips, J. S. Syrus, A. V. Zaitsev, C. W. Hennige, "Noninvasive Surgery of Prostate Tissue by High-Intensity Focused Ultrasound," IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. Vol. 43, No. 6, November 1996. [Paper]
K. Nakamura, "Treatment of BPH (Benign Prostatic Hypertrophy): High Intensity Focused Ultrasound (HIFU)," Current Therapy, November 1996 Vol. 14 No.11.
S. Madersbacher, C. H. Klinger, G. Schatzl, C. P. Schmidbaur, and M. Marberger, "The Impact of Transrectal High intensity Focused Ultrasound on Prostatic Obstruction in BPH Assessed by Pressure Flow Studies," EUR. UROL. 30, 437-445, 1996.
S. Madersbacher, and M. Marberger, "High Intensity Ultrasound in Urology," Japanese Journal of Endourology and ESWL, Vol. 9, no. 1, 1996. [Paper]
T. Ebert, D. Sadler, S. Miller, B. Schmitz-Drager, and R. Ackerman, "High Intensity Focused Ultrasound in the Treatment of Benign Hypertrophy of the Prostate," Urologe [A] 34; 404-408, 1995.
F. Fry, N. Sanghvi, R. Foster, R. Bihrle, and C. Hennige, "Ultrasound and Microbubbles: Their Generation, Detection and Potential Utilization in Tissue and Organ Therapy - Experimental," Ultrasound in Medicine & Biology, Vol. 31, No. 9; 1227-1237, 1995. [Paper]
R. Birhrle, R. S. Foster, N. T. Sanghvi, J. P. Donohue, P. J. Hood, "High Intensity Focused Ultrasound for the Treatment of BPH," Urology, Vol. 151; 1271-1275, 1994.
S. Madersbacher, C. Kratzik, M. Susani, M. Marberger, "Tissue Ablation in Benign Prostatic Hyperplasia with High Intensity Focused Ultrasound," J. Urology, Vol. 152; 1956-1961, 1994. [Paper]
R. S. Foster, R. Birhle, N. T. Sanghvi, and J. P. Donohue, "High Intensity Focused Ultrasound for the Treatment of BPH," Seminars in Urology, Vol. XII ; 200-204, August 1994. [Paper]
N. T. Sanghvi, R. S. Foster, F. J. Fry, R. Bihrle, C. Hennige, L. Hennige, "Ultrasound Intracavitary System for Imaging, Therapy, and Treatment of Focal Disease," IEEE Ultrasound Symp. Pros., Cat. No. 92CH3118-7; 1249-1253, 1992.
W. K. Mebust, H. L. Holtgrewe, A. T. K. Cockett, "Transurethral Prostatectomy; Immediate and Postoperative Complications," J. Urology 141; 243-247, 1989.
Transducers and Phased Arrays
S. Umemura, K. Sasaki, K. Kawabata, T. Azuma, and N.T. Sanghvi, "Coagulation of Swine Liver and Canine Prostate with a Prototype Split-Focus Transducer," IEEE Ultrasonics Symposium Proceedings, 1999, pp. 1439-1442. [Paper]
J. Wu, N.T. Sanghvi, M. Phillips, M. Kuznetsov, R.S. Foster, R. Bihrle, and T.A. Gardner, "Experimental Studies of Using a Split Beam Transducer for Prostate Cancer Therapy in Comparison to Single Beam Transducer," IEEE Ultrasonics Symposium Proceedings, 1999, pp.1443-1446. [Paper]
J.S. Tan, L.A. Frizzell, N.T. Sanghvi, and R. Seip, "Design of Focused Ultrasound Arrays for Prostate Treatment," IEEE Ultrasonics Symposium Proceedings, Vol. 2, 2000, pp. 1247-1251. [Paper]
J.S. Tan, L. Frizzell, N. Sanghvi, S. Wu, R. Seip, and J. Kouzmanoff, "Ultrasound Phased Arrays for Prostate Treatment," Journal of the Acoustical Society of America, Vol. 109, No. 6, June 2001, pp. 3055-3064. [Paper]
R. Seip, N. Sanghvi, T. Uchida, and S. Umemura, "Comparison of Split-Beam Transducer Geometries and Excitation Configurations for Transrectal Prostate HIFU Treatments," IEEE Ultrasonics Symposium Proceedings, Vol. 2, 2001, pp. 1343-1346. [Paper]
R. Seip, W. Chen, J. Tavakkoli, L.A. Frizzell, and N.T. Sanghvi, "High-Intensity Focused Ultrasound (HIFU) Phased Arrays: Recent Developments in Transrectal Transducers and Driving Electronics Design," Proc. of the International Symposium on Therapeutic Ultrasound, 2003, pp.423-428. [Paper] [Poster]
K. Ishida, J. Kubota, T. Mitake, R. Carlson, R. Seip, N. Sanghvi, T. Azuma, K. Sasaki, K. Kawabata, and S. Umemura, "Development and animal experiment of variable focusing HIFU system for prostate cancer treatment," Proc. of the International Symposium on Therapeutic Ultrasound, 2003, pp. 382-387. [Paper] [Presentation]
R. Seip, W. Chen, R. Carlson, L. Frizzell, G. Warren, N. Smith, K. Saleh, G. Gerber, K. Shung, H. Guo, and N. T. Sanghvi, "Annular and Cylindrical Phased Array Geometries for Transrectal High-Intensity Focused Ultrasound (HIFU) using PZT and Piezocomposite Materials," to appear in the Proc. of the International Symposium on Therapeutic Ultrasound, 2004. [Paper]
Treatment Monitoring and Lesion Detection
R. Seip, J. Tavakkoli, R. Carlson, A. Wunderlich, N. Sanghvi, K. Dines, and T. Gardner, "High-Intensity Focused Ultrasound (HIFU) Multiple Lesion Imaging: Comparison of Detection Algorithms for Real-Time Treatment Control," IEEE Ultrasonics Symposium Proceedings, 2002, pp. 1395-1398. [Paper]
R. Seip, J. Tavakkoli, K. Dines, A. Wunderlich, N. T. Sanghvi, and L.A. Crum, "Real-time Detection of Multiple Lesions during High Intensity Focused Ultrasound (HIFU) Treatments," Proc. of the International Symposium on Therapeutic Ultrasound, 2002, pp. 168-175. [Paper] [Movie: Real-Time Lesion Detection In In-Vitro Chicken Tissue] [Movie: Real-Time Lesion Detection In In-Vivo Canine Prostate, 100% Detection] [Movie: Real-Time Lesion Detection In In-Vivo Canine Prostate, 83% Detection]
N.T. Sanghvi, A. Wunderlich, R. Seip, J. Tavakkoli, K. Dines, M. Bailey, and L. Crum, "Decision Theory Applied to High-Intensity Focused Ultrasound (HIFU) Treatment Evaluation," 2003 AIUM Annual Meeting, June 1-4, 2003, Montreal, Quebec, Canada. [Presentation]
M. Bailey, J. Reed, A. Anand, P. Kaczkowski, W. Kreider, S. Vaezy, M. Nakazawa, L. Crum, R. Seip, J. Tavakkoli, and N. Sanghvi, "Caviation Detection and Suppression in HIFU," Proc. of the International Symposium on Therapeutic Ultrasound, 2003, pp. 43-48. [Poster]
W. Chen, R. Carlson, R. Fedewa, R. Seip, N. T. Sanghvi, K. A. Dines, R. Pfile, M. A. Penna, and T. A. Gardner, "The Detection and Exclusion of Prostate Neuro-Vascular Bundle (NVB) in Automated HIFU Treatment Planning Using a Pulsed-Wave Doppler Ultrasound System," to appear in the Proc. of the International Symposium on Therapeutic Ultrasound, 2004. [Paper]
Laparoscopic and Catheter-Based HIFU Applications
R. Seip, M. Biswas, M. Kuznetsov, T. Gardener, and N. Sanghvi, "Transurethral High Intensity Focused Ultrasound: Catheter Prototypes and Experimental Results," IEEE Ultrasonics Symposium Proceedings, Vol. 2, 2000, pp. 1413-1416. [Paper]
J. Tavakkoli, R. Seip, V. Rao, R. Patterson, A. Evan, A. Shalhav, and N. Sanghvi, "A Laparoscopic HIFU Probe for Kidney Ablation prior to Partial Nephrectomy, " IEEE Ultrasonics Symposium Proceedings, Vol. 2, 2001, pp. 1369-1372. [Paper]
N.T. Sanghvi, J. Tavakkoli, V. Rao, M. Biswas, R. Seip, E. Barret, and A.L. Shalhav, "Laparoscopically Deliverd HIFU for Partial Renal Ablation," 17th International Congress on Acoustics, 2-7 September 2001, Rome, Italy. [Paper]
J. Tavakkoli, V. Rao, R. Seip, R.F. Paterson, E. Barret, L. Cheng, A.L. Shalhav, and N.T. Sanghvi, "Laparoscopic High Intensity Focused Ultrasound: Application to Kidney Ablation," Proc. of the International Symposium on Therapeutic Ultrasound, 2002, pp. 202-210. [Paper]
J. Tavakkoli, A. Mehta, C. Miller, R. Seip, N.T. Sanghvi, L. Cheng, T.A. Gardner, and A.L. Shalhav, "A Laparoscopic HIFU Probe with Integrated Phased Array Ultrasound Imaging," International Symposium on Therapeutic Ultrasound, 2003, pp. 417-422. [Paper] [Poster]
Other Research and Development Projects
R. Seip, N.T. Sanghvi, R. Carlson, J. Tavakkoli, K. Dines, T.A. Gardner, and T. Uchida, "Sonablate® 500: A Novel Platform for Transrectal Image-Guided HIFU Treatment of Localized Prostate Cancer," presented at the 32nd Annual Symposium of the Ultrasonic Industry Association (UIA), 2002. [Presentation]
R. Seip, D. Shaeffer, P. Lawrence, T.A. Gardner, M.O. Koch, L. Cheng, A. Wunderlich, C. Miller, and N.T. Sanghvi, "Feasibility Study for the Treatment of Brachytherapy Failure Prostate Cancer using High-Intensity Focused Ultrasound," International Symposium on Therapeutic Ultrasound, 2003, pp. 429-434. [Paper]
R. Seip, M. Penna, R. Carlson, W. Chen, N. Sanghvi, K. Dines, R. Pfile, T. Gardner, and M. Koch, "Automated HIFU Treatment Planning and Execution based on 3D Modeling of the Prostate, Urethra, and Rectal Wall", IEEE Ultrasonics Symposium Proceedings, 2004. [Paper] [Poster]
R. Seip, R. Carlson, R. Fedewa, W.H. Chen, and N.T. Sanghvi, "The Sonablate® Platform: Evolution, Capabilities, and Enhancements for Ultrasound Image-Guided HIFU Treatments of Localized Prostate Cancer," presented at the International Symposium on Therapeutic Ultrasound, Boston, 2005. [Presentation]
R. Seip, A. Katny, W. Chen, N. Sanghvi, K. Dines, and J. Wheeler, "Remotely Operated Robotic High Intensity Focused Ultrasound (HIFU) Manipulator System for Critical Systems for Trauma and Transport (CSTAT)," presented at the IEEE Ultrasonics Symposium Proceedings, 2006. [Abstract]
R. Fedewa, R. Carlson, R. Seip, N. Sanghvi, M. Koch, T. Gardner, "Prediction of Success for HIFU Treatments of Prostate Cancer Based on Acoustic Energy Density," presented at the IEEE Ultrasonics Symposium Proceedings, 2006. [Abstract]
The Sonablate® is an investigational device limited by Federal Law to investigational use in the United States.
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